Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide.

@article{Wittmann1999SuppressionOI,
  title={Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide.},
  author={Miriam Wittmann and Veronika Larsson and Peter Georg Schmidt and Gabriele Begemann and Alexander Kapp and Thomas Werfel},
  journal={Blood},
  year={1999},
  volume={94 5},
  pages={
          1717-26
        }
}
Interleukin-12 (IL-12) is a potent proinflammatory and immunoregulatory cytokine skewing T lymphocytes to express a type 1 cytokine pattern. Optimal expression of IL-12 mRNA and bioactivity in vitro requires specific priming of monocytes by interferon-gamma (IFN-gamma) or granulocyte-macrophage colony-stimulating factor (GM-CSF) before lipopolysaccharide (LPS) stimulation. We show here for the first time that the production of IL-12 by IFN-gamma- or GM-CSF-primed human monocytes can be… CONTINUE READING

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