Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.

@article{Watanabe1995SuppressionOI,
  title={Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.},
  author={Minoru Watanabe and Yoko Kawase and Jutarou Tanabe and Kyung Rak Min and Suetsugu Mue and Kazuo Ohuchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={808-14}
}
In human umbilical endothelial cells, treatment with tumor necrosis factor (TNF)-alpha stimulated the production of cell-associated interleukin (IL)-1 alpha. Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha. However, concentrations of 6-keto-prostaglandin F1 alpha in the conditioned medium were increased to a greater extent by… CONTINUE READING