Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.

@article{Tsiperson2013SuppressionOI,
  title={Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.},
  author={Vladislav Tsiperson and Ross C. Gruber and Michael F. Goldberg and Ayana Jordan and Jason G. Weinger and Fernando Macian and Bridget Shafit-Zagardo},
  journal={Journal of immunology},
  year={2013},
  volume={190 4},
  pages={1528-39}
}
AKT3, a member of the serine/threonine kinase AKT family, is involved in a variety of biologic processes. AKT3 is expressed in immune cells and is the major AKT isoform in the CNS representing 30% of the total AKT expressed in spinal cord, and 50% in the brain. Myelin-oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is a mouse model in which lymphocytes and monocytes enter the CNS, resulting in inflammation, demyelination, and axonal injury. We hypothesized… CONTINUE READING

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