Suppression of inflammation and acute lung injury by the transcription factor Miz1 via repression of C/EBP-δ

@inproceedings{DoUmehara2013SuppressionOI,
  title={Suppression of inflammation and acute lung injury by the transcription factor Miz1 via repression of C/EBP-δ},
  author={Hanh Chi Do-Umehara and Cong Chen and Daniela Urich and Liang Zhou and Ju Qiu and Samuel Jang and Alia Zander and Margaret A. Baker and Martin Eilers and Peter H S Sporn and Karen M Ridge and Jacob I Sznajder and G. R. Scott Budinger and G{\"o}khan M Mutlu and Anning Lin and Jing ai Liu},
  booktitle={Nature Immunology},
  year={2013}
}
Inflammation is essential for host defense but can cause tissue damage and organ failure if unchecked. How the inflammation is resolved remains elusive. Here we report that the transcription factor Miz1 was required for terminating lipopolysaccharide (LPS)-induced inflammation. Genetic disruption of the Miz1 POZ domain, which is essential for the transactivation or repression activity of Miz1, resulted in hyperinflammation, lung injury and greater mortality in LPS-treated mice but a lower… CONTINUE READING