Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678.

  title={Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678.},
  author={Masashi Deguchi and J. Kishino and M. Hattori and Y. Furue and M. Yamamoto and Izumi Mochizuki and Motofumi Iguchi and Y. Hirano and Kanji Hojou and M. Nagira and Y. Nishitani and Ken-ichi Okazaki and K. Yasui and A. Arimura},
  journal={European journal of pharmacology},
  volume={601 1-3},
  • Masashi Deguchi, J. Kishino, +11 authors A. Arimura
  • Published 2008
  • Chemistry, Medicine
  • European journal of pharmacology
  • We discovered a novel dihydroorotate dehydrogenase (DHO-DH) inhibitor, S-2678 ([2-fluoro-2',5'-dimethyl-4'-[6-(3-methyl-2-butenyloxy) pyridin-3-yl] biphenyl-4-yl]-(3-methyl-2-butenyl) amine). Its inhibitory activity against DHO-DH was more potent than that of A77 1726, an active metabolite of the anti-rheumatic drug leflunomide. S-2678 suppressed immunoglobulin production in mouse B cells and human peripheral blood mononuclear cells in vitro, with little or no inhibition of cell proliferation… CONTINUE READING
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