Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone.

@article{Pestka1987SuppressionOI,
  title={Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone.},
  author={James J. Pestka and Jason C. H. Tai and Mary F Witt and Donald E. Dixon and Johan Forsell},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1987},
  volume={25 4},
  pages={297-304}
}
The effect that dietary exposure to the naturally-occurring Fusarium graminearum toxins deoxynivalenol (DON) and zearalenone (ZEA) may have on immune function was assessed in the B6C3F1 mouse. Dietary DON depressed the plaque-forming response to sheep red blood cells, the delayed hypersensitivity response to keyhole limpet haemocyanin and the ability to resist Listeria monocytogenes. Listerial resistance was similarly decreased in control mice fed restricted diets comparable to the dietary… CONTINUE READING
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