Suppression of human interferon production by inhibitors of glycosylation.

@article{Havell1975SuppressionOH,
  title={Suppression of human interferon production by inhibitors of glycosylation.},
  author={E A Havell and Jan T. Vil{\vc}ek and Ernesto Falcoff and Brian Berman},
  journal={Virology},
  year={1975},
  volume={63 2},
  pages={
          475-83
        }
}
Abstract Treatment of diploid human foreskin cell cultures with either 2-deoxy- d -glucose or d -glucosamine resulted in dose-dependent inhibition of interferon production induced with polyinosinate-polycytidylate [poly(I) · poly(C)]. This inhibitory action was readily demonstrable even if the addition of the inhibitor was delayed until 1.5 hr after induction. The appearance of intracellular interferon activity was also inhibited, suggesting that synthesis of biologically active interferon, and… Expand

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