Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.

@article{Yang1997SuppressionOH,
  title={Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.},
  author={Otto O Yang and Spyros A. Kalams and Alicja K. Trocha and Hong L Cao and Andrew D Luster and R Paul Johnson and Bruce D. Walker},
  journal={Journal of virology},
  year={1997},
  volume={71 4},
  pages={3120-8}
}
Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both… CONTINUE READING

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