Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter.

@article{Shearer2002SuppressionOH,
  title={Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter.},
  author={William Thomas Shearer and B N Lee and Stanley G. Cron and Howard M. Rosenblatt and Elliot O'Brian Smith and Desmond J Lugg and P. M. Nickolls and Robert M Sharp and Karl Rollings and James M. Reuben},
  journal={The Journal of allergy and clinical immunology},
  year={2002},
  volume={109 5},
  pages={854-7}
}
Cellular immune function has been shown to be decreased and latent virus shedding to be increased in human beings isolated during the Antarctic winter, a model used for assessing some effects of space flight. However, the balance of proinflammatory (IFN-gamma) and anti-inflammatory (IL-10 and IL-1RA) cytokines has not previously been evaluated. We therefore sought to determine whether isolation during the Antarctic winter would alter the proinflammatory and anti-inflammatory cytokine balance… CONTINUE READING

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