Suppression of human B lymphocyte function by cyclophosphamide.

@article{Cupps1982SuppressionOH,
  title={Suppression of human B lymphocyte function by cyclophosphamide.},
  author={Thomas R. Cupps and Lynn C. Edgar and AnthonyS. Fauci},
  journal={Journal of immunology},
  year={1982},
  volume={128 6},
  pages={
          2453-7
        }
}
The immune responses of 16 patients with nonneoplastic immune mediated diseases including Wegener's granulomatosis, systemic necrotizing vasculitis, cutaneous vasculitis, and relapsing nodular panniculitis were evaluated before and during therapy with chronic low-dose (2 mg/kg/day) cyclophosphamide. A striking selective suppression of B cell function was noted as measured by PWM-induced immunoglobulin secretion. This suppression was a direct effect on the B cells themselves because T cell… CONTINUE READING

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