Suppression of histone deacetylase 11 promotes expression of IL-10 in Kupffer cells and induces tolerance following orthotopic liver transplantation in rats.

@article{Lian2012SuppressionOH,
  title={Suppression of histone deacetylase 11 promotes expression of IL-10 in Kupffer cells and induces tolerance following orthotopic liver transplantation in rats.},
  author={Zheng-rong Lian and Yu-fei Xu and Xiaobo Wang and Jian-ping Gong and Zuo-jin Liu},
  journal={The Journal of surgical research},
  year={2012},
  volume={174 2},
  pages={359-68}
}
BACKGROUND Suppression of histone deacetylase 11 (HDAC11) can promote IL-10 expression in mouse macrophages RAW264.7 and induce immune tolerance. This study is to further investigate the role of HDAC11 in tolerance induction via Kupffer cells (KCs) following orthotopic liver transplantation (OLT) in rats. MATERIALS AND METHODS KCs isolated from BALB/c… CONTINUE READING