Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid level

@article{Liu2003SuppressionOH,
  title={Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid level},
  author={H. Liu and J. Kaur and K. Dashtipour and R. Kinyamu and C. Ribak and L. Friedman},
  journal={Experimental Neurology},
  year={2003},
  volume={184},
  pages={196-213}
}
Seizures increase dentate granule cell proliferation in adult rats but decrease proliferation in young pups. The particular period and number of perinatal seizures required to cause newborn granule cell suppression in development are unknown. Therefore, we examined cell proliferation with bromodeoxyuridine (BrdU) immunohistochemistry during the peak of neurogenesis (e.g., P6 and P9) and at later postnatal ages (e.g., P13, P20, or P30) following single and multiple episodes of perinatal status… Expand
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