Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes.

@article{Yamazoe1989SuppressionOH,
  title={Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes.},
  author={Y. Yamazoe and Nobuhiro Murayama and Miki Shimada and Susumu Imaoka and Yoshihiko Funae and Ryuichi Kato},
  journal={Molecular pharmacology},
  year={1989},
  volume={36 5},
  pages={716-22}
}
The mechanism of the suppression of an ethanol-inducible cytochrome P-450 (P-450DM/j) by pituitary hormone has been studied in rats. The hepatic content of P-450DM/j protein quantitated by Western blots was low but was 2-fold higher in male than female untreated rats (75 and 34 pmol/mg of protein, respectively). The content was increased 2.6-fold (male) and 5.6-fold (female) by hypophysectomy and the sex-related difference was abolished. Treatment of hypophysectomized rats with human growth… CONTINUE READING