Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells

@article{Mori2017SuppressionOH,
  title={Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells},
  author={Yuki Mori and Ryu Terauchi and Toshiharu Shirai and Shinji Tsuchida and Naoki Mizoshiri and Yuji Arai and Tsunao Kishida and Hiroyoshi Fujiwara and Osam Mazda and Toshikazu Kubo},
  journal={Cell Stress and Chaperones},
  year={2017},
  volume={22},
  pages={699-706}
}
Although advances in chemotherapy have improved the prognosis for osteosarcoma, some patients do not respond sufficiently to treatment. Heat shock protein 70 (Hsp70) is expressed at high levels in cancer cells and attenuates the therapeutic efficacy of anticancer agents, resulting in a poorer prognosis. This study investigated whether small interfering RNA (siRNA)-mediated inhibition of Hsp70 expression in an osteosarcoma cell line would enhance sensitivity to cisplatin. The expression of Hsp70… CONTINUE READING

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