Suppression of heart NF-κB p65 expression by jugular vein injection of RNAi in mice.

@article{Ye2010SuppressionOH,
  title={Suppression of heart NF-κB p65 expression by jugular vein injection of RNAi in mice.},
  author={Wenxue Ye and Xiaomei Ten and Man He and Y Yu and H Huang and Y-x Hu and Yen-Jen Chen and X Zhou and Zheng Nan Shen},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2010},
  volume={32 6},
  pages={391-400}
}
The nuclear factor-kappaB (NF-κB) in cardiac vascular endothelial cells (type II VEC) is a key factor that activates delayed xenograft rejection (DXR), and therefore inhibition of NF-κB gene expression may alleviate post-transplant rejection. siRNA technology was used to inhibit NF-κB p65 gene expression in ICR mice. After jugular vein injection of siRNA/in vivo-jetPEI complex, fluorescence levels of FAM-labeled siRNA in hearts and lungs were much higher after jugular vein injection than tail… CONTINUE READING