Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo.

@article{Zhu2011SuppressionOG,
  title={Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo.},
  author={Qing Zhu and Jun Yang and Suxia Han and Jihong Liu and Jeffery M. Holzbeierlein and James Brantley Thrasher and Benyi Li},
  journal={The Prostate},
  year={2011},
  volume={71 8},
  pages={835-45}
}
BACKGROUND Glycogen synthase kinase 3 (GSK-3) has been regarded as a potential therapeutic target for multiple human cancers. We previously reported that suppression of GSK-3 activity with lithium chloride (LiCl) or small chemical inhibitors impaired cellular DNA synthesis and reduced cell proliferation in prostate cancer cells. Therefore, in this study, we extended this in vitro findings to in vivo settings in order to establish a proof of concept that inhibition of GSK-3 activity is feasible… CONTINUE READING