Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.

@article{MinaOsorio2013SuppressionOG,
  title={Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.},
  author={Paola Mina-Osorio and Jacob J LaStant and Natalie D. Keirstead and Toni Whittard and Julia Marie Ayala and Stella Stefanova and Rosario L{\'o}pez-Navarrete Garrido and Nena M. Dimaano and Holly Hilton and Mario Giron and K. S. Y. Lau and Julie S. Hang and Jennifer Postelnek and Yong geun Kim and Soo Ki Min and Alka J Patel and John N. Woods and Meera Ramanujam and Julie Demartino and Satwant K. Narula and Daigen Xu},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 9},
  pages={
          2380-91
        }
}
OBJECTIVE Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR) and Fcγ receptor signaling and is efficacious in animal models of arthritis. The aim of this study was to examine the potential efficacy of BTK in systemic lupus erythematosus (SLE), using an NZB × NZW mouse model of spontaneous SLE. METHODS Mice received RN486 or its vehicle (administered in chow) at a… CONTINUE READING
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