Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.

@article{Zhang2006SuppressionOG,
  title={Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.},
  author={Chaoying Zhang and Tania M Roberts and Jay Yang and Ridhdhi Desai and Grant W Brown},
  journal={DNA repair},
  year={2006},
  volume={5 3},
  pages={336-46}
}
Replication forks can stall spontaneously at specific sites in the genome, and upon encountering DNA lesions resulting from chemical or radiation damage. In Saccharomyces cerevisiae proteins implicated in processing of stalled replication forks include those encoded by the SGS1, TOP3, MUS81, MMS4, SLX1, SLX4, SLX5/HEX3, and SLX8 genes. We tested the roles of these genes in suppressing gross chromosomal rearrangements (GCRs), which include translocations, large interstitial deletions, and loss… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…