Suppression of gastric ulcer induced by stress and HCL-ethanol by intravenously administered metallothionein-II.

Abstract

A metallothionein isoform metallothionein-II was isolated from the livers of zinc acetate-treated rats. Metallothionein-II, which showed a single band on polyacrylamide gel electrophoresis, was subjected to two kinds of anti-ulcer screening systems. It was shown that intravenously administered metallothionein-II suppressed the formation of rat water-immersion stress- and HCl-ethanol-induced gastric ulcer significantly. The effect may partly be derived from the zinc contained in the metallothionein-II. However, the effect of metallothionein-II was much stronger than that of an equivalent mole of zinc. Apparently, metallothionein-II had an anti-ulcerogenic activity not based on the effect of intrinsic zinc.

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@article{Mimura1988SuppressionOG, title={Suppression of gastric ulcer induced by stress and HCL-ethanol by intravenously administered metallothionein-II.}, author={Toshihide Mimura and Kazutake Tsujikawa and Nobuyuki Yasuda and Hiromu Nakajima and Munetada Haruyama and Takumi Ohmura and Masaru Okabe}, journal={Biochemical and biophysical research communications}, year={1988}, volume={151 2}, pages={725-9} }