Corpus ID: 45632368

Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine.

@article{Hoffman1986SuppressionOF,
  title={Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine.},
  author={Brian B. Hoffman and E. Dall'aglio and Carol Hollenbeck and H Chang and Gerald M. Reaven},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={239 3},
  pages={
          715-8
        }
}
  • Brian B. Hoffman, E. Dall'aglio, +2 authors Gerald M. Reaven
  • Published in
    The Journal of pharmacology…
    1986
  • Chemistry, Medicine
  • Activation of adenosine receptors leads to the inhibition of lipolysis in the fat cells of several species including humans. We have examined the effects of the adenosine analog phenylisopropyladenosine (PIA) on lipolysis in vivo in intact rats. PIA suppresses markedly serum-free fatty acid (FFA) concentrations when injected s.c. (-)-PIA is more potent than (+)-PIA in suppressing FFA concentrations; also, this effect of (-)-PIA is blocked by the adenosine receptor antagonist 8-(p-sulfophenyl… CONTINUE READING

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