Suppression of fibroblast cell cycle progression in G1 phase by N-acetylcysteine.

  title={Suppression of fibroblast cell cycle progression in G1 phase by N-acetylcysteine.},
  author={Madhavi Sekharam and Andrea Trotti and Jess M. Cunnick and Jie Wu},
  journal={Toxicology and applied pharmacology},
  volume={149 2},
The antioxidant N-acetyl-L-cysteine (NAC) has been increasingly used as an experimental tool to assess involvement of reactive oxygen species in cell signaling and is being evaluated as a preventive and therapeutic agent for cancer and pulmonary diseases related to inflammation and oxidative stress. However, a detailed characterization of the effect of NAC on cell cycle progression has not been reported. In the present study, modulation of cell cycle progression by NAC was analyzed in mouse… CONTINUE READING


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