Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.

@article{Park2003SuppressionOE,
  title={Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.},
  author={M Park and Jung-A Choi and Min-Jeong Kim and Hong-Duck Um and Sangwoo Bae and C Kang and C Cho and Seongman Kang and Hee Yong Chung and Yun-Sil Lee and Su-Jae Lee},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 50},
  pages={50624-34}
}
We previously demonstrated that the phytosphingosine-induced apoptosis was accompanied by the concomitant induction of both the caspase-8-mediated and mitochondrial activation-mediated apoptosis pathways. In the present study, we investigated the role of mitogen-activated protein kinases (MAPKs) in the activation of these two distinct cell death pathways induced by phytosphingosine in human cancer cells. Phytosphingosine caused strong induction of caspase-8 activity and caspase-independent Bax… CONTINUE READING

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