Suppression of experimental systemic lupus erythematosus (SLE) with specific anti-idiotypic antibody-saporin conjugate.

@article{Blank1994SuppressionOE,
  title={Suppression of experimental systemic lupus erythematosus (SLE) with specific anti-idiotypic antibody-saporin conjugate.},
  author={Miri Blank and Jiradej Manosroi and Yaron Tomer and Aranya Manosroi and Jury Kopolovic and S Charcon-Polak and Yehuda Shoenfeld},
  journal={Clinical and experimental immunology},
  year={1994},
  volume={98 3},
  pages={434-41}
}
The importance of the idiotypic network is represented in experimental SLE induced by active immunization of naive mice with an anti-DNA idiotype (Ab1) emulsified in adjuvant. The mice after 4 months of incubation generate Ab3 having anti-DNA activity. In addition, the mice develop other serological markers for SLE associated with clinical and… CONTINUE READING