Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats.

@article{Voorthuis1990SuppressionOE,
  title={Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats.},
  author={J A Voorthuis and Bernard M. J. Uitdehaag and Corline J A de Groot and Peter H Goede and Peter H van der Meide and Christine D. Dijkstra},
  journal={Clinical and experimental immunology},
  year={1990},
  volume={81 2},
  pages={183-8}
}
Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS) which causes paralysis. Several studies have reported the involvement of Ia antigen-expressing cells in the pathogenesis of EAE. Interferon-gamma (IFN-gamma) can induce Ia antigen expression on a wide range of cells. We examined the effect of IFN-gamma on EAE in Lewis rats. Systemically administered IFN-gamma did not change the disease course of EAE, whereas IFN-gamma applied… CONTINUE READING