Suppression of ethanol-induced locomotor stimulation by GABA-like drugs

@article{Cott1976SuppressionOE,
  title={Suppression of ethanol-induced locomotor stimulation by GABA-like drugs},
  author={Jerry M. Cott and Arvid Carlsson and J{\"o}rgen A. Engel and Margit Lindqvist},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1976},
  volume={295},
  pages={203-209}
}
SummaryEthanol (2.4 g/kg) was given intraperitoneally to mice and was found to cause a marked increase in spontaneous locomotor activity. When mice were pretreated with low doses of agents which mimic or augment the action of GABA (γ-hydroxybutyric acid, baclophen, or aminooxyacetic acid) the ethanol-induced locomotor stimulation was completely eliminated. Baclophen (10 mg/kg) was found to cause an initial increase followed by a later decrease in synthesis of catecholamines, as measured by the… CONTINUE READING
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