Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.

@article{Nofer2001SuppressionOE,
  title={Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.},
  author={J. R. Nofer and Bodo Levkau and Iza Wolinska and Ralf Junker and Manfred Fobker and Arnold von Eckardstein and Udo Seedorf and G. A{\ss}mann},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 37},
  pages={
          34480-5
        }
}
Apoptotic cell death following injury of vascular endothelium is assumed to play an important role in the pathogenesis of atherosclerosis. In this report, we demonstrate that high density lipoproteins (HDL), a major anti-atherogenic lipoprotein fraction, protect endothelial cells against growth factor deprivation-induced apoptosis. HDL blocked the mitochondrial pathway of apoptosis by inhibiting dissipation of mitochondrial potential (Deltapsi(m)), generation of reactive oxygen species, and… CONTINUE READING
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