Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).

@article{Christgau2004SuppressionOE,
  title={Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).},
  author={Stephan Christgau and L{\'a}szl{\'o} B. Tank{\'o} and Paul A C Cloos and Ulrik Mouritzen and Claus Christiansen and Jean-Marie Delaiss{\'e} and Pernille H\oegh-Andersen},
  journal={Menopause},
  year={2004},
  volume={11 5},
  pages={508-18}
}
OBJECTIVE Several observational studies indicate that estrogen deficiency increases the incidence of osteoarthritis in postmenopausal women. To validate this observation, we investigated the effects of ovariectomy (OVX) on cartilage erosion in rats using histology and an established bio-assay of cartilage-specific collagen type II degradation products (CTX-II). Furthermore, we investigated whether estrogen and levormeloxifene, a selective estrogen-receptor modulator (SERM), can prevent the OVX… CONTINUE READING

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