Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition.

@article{Wu2006SuppressionOD,
  title={Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition.},
  author={Yuejin Wu and Ayumi Shintani and Chad E. Grueter and Rong Zhang and Yue mei Hou and Jinying Yang and Evangelia G Kranias and Roger J Colbran and Mark E. Anderson},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 2},
  pages={213-23}
}
The multifunctional Ca(2+) and calmodulin-dependent protein kinase II (CaMKII) is important for regulating L-type Ca(2+) current (I(Ca)) and cytoplasmic Ca(2+) (Ca(2+)(i)) uptake and release from the sarcoplasmic reticulum (SR), key elements of the 'Ca(2+)-induced Ca(2+) release' (CICR) mechanism. However, the effects of chronic CaMKII inhibition on Ca(2+)(i) responses during CICR are unknown. We hypothesized that chronic CaMKII inhibition significantly affects CICR in ventricular myocytes. We… CONTINUE READING

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