Suppression of dsDNA-specific B lymphocytes reduces disease symptoms in SCID model of mouse lupus.

Abstract

Self-specific B cells play a main role in the pathogenesis of lupus. This autoimmune disease is characterized by the generation of autoantibodies against self antigens, and the elimination of B and T cells involved in the pathological immune response is a logical approach for effective therapy. We have previously constructed a chimeric molecule by coupling… (More)
DOI: 10.3109/08916934.2014.883502

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