Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway.

@article{Nagai2007SuppressionOD,
  title={Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway.},
  author={Norihiro Nagai and Kanako Izumi-Nagai and Yuichi Oike and Takashi Koto and Shingo Satofuka and Yoko Ozawa and Kenji Yamashiro and Makoto Inoue and Kazuo Tsubota and Kazuo Umezawa and Susumu Ishida},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 9},
  pages={4342-50}
}
PURPOSE To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation. METHODS Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week. Retinal mRNA and protein levels of the RAS components were… CONTINUE READING

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Inflammation in diabetic retinopathy.

Progress in retinal and eye research • 2011
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