Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma

@article{Herbert2008SuppressionOC,
  title={Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma},
  author={Cristan Herbert and Anusha Hettiaratchi and Dianne C. Webb and Paul S Thomas and Paul S. Foster and Rakesh K Kumar},
  journal={Clinical \& Experimental Allergy},
  year={2008},
  volume={38}
}
Background In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase‐4 inhibitor). 
Effect of roflumilast on airway remodelling in a murine model of chronic asthma
  • S. Kim, J. Kim, +6 authors H. Yoon
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2016
TLDR
Roflumilast is a selective phosphodiesterase‐4 inhibitor that has an anti‐inflammatory effect in chronic obstructive pulmonary disease (COPD). Expand
ISU201 Enhances the Resolution of Airway Inflammation in a Mouse Model of an Acute Exacerbation of Asthma
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The ability of ISU201 to promote resolution of inflammation suggests that it may have potential as an alternative to glucocorticoids in the management of asthma, including when administered after the onset of an acute exacerbation. Expand
Anti-Inflammatory and Anti-Remodelling Effects of ISU201, a Modified Form of the Extracellular Domain of Human BST2, in Experimental Models of Asthma: Association with Inhibition of Histone Acetylation
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It is concluded that in these models of asthma, ISU201 is a broad-spectrum inhibitor of both airway inflammation and remodelling, and could potentially be an alternative or an adjunct to glucocorticoids for the treatment of asthma. Expand
Interleukin-17 regulation: an attractive therapeutic approach for asthma
TLDR
The role of IL-17 in the context of allergic airway inflammation is summarized and the therapeutic potential of various strategies targeting IL- 17 for asthma is discussed. Expand
Interleukin-17 Signalling in a Murine Model of Mild Chronic Asthma
TLDR
Investigating the role of Th17 cell-derived cytokines in the pathogenesis of airway inflammation and remodelling in mild asthma found that IL-17A appears to have a role in the goblet cell response in the airways, and Th17 cells are induced in this model of mild chronic asthma. Expand
Inhibition of airway inflammation and remodeling by sitagliptin in murine chronic asthma.
  • M. A. Nader
  • Medicine
  • International immunopharmacology
  • 2015
TLDR
Data indicate that sitagliptin like dexamethasone may play a beneficial role reducing airway inflammation and remodeling in chronic murine model of asthma. Expand
Reviewregulation: an attractive therapeutic approach for asthma
TLDR
The role of IL-17 in the context of allergic airway inflammation is summarized and the therapeutic potential of various strategies targeting IL- 17 for asthma is discussed. Expand
Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma
TLDR
Data indicate that in this model of an acute exacerbation of chronic asthma, IL-33 drives activation of AM and has an important role in the pathogenesis of airway inflammation. Expand
Expression of Th-17 related cytokines (IL-17A and F) in severe asthma
TLDR
The expression of both IL-17A and F were shown to be increased in severe asthmatic airways compared to mild asthmatics and control subjects, consistent with the possible role of IL- 17 family in steroid hyperresponsive disorders, including rheumatoid arthritis, psoriasis and refractory asthma. Expand
Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A.
BACKGROUND β-Agonists are used for relief and control of asthma symptoms by reversing bronchoconstriction. They might also have anti-inflammatory properties, but the underpinning mechanisms remainExpand
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References

SHOWING 1-10 OF 62 REFERENCES
Role of interleukin‐13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
TLDR
Background Interleukin‐13 is believed to be important in asthmatic inflammation and airway hyper‐reactivity and may play a role in the development of asthma. Expand
Dissociation of T helper type 2 cytokine‐dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma
Background Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the pathogenesis of asthma.
Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis
  • R. K. Kumar, C. Herbert, P. Foster
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2004
TLDR
This data indicates that suppression of growth factors produced by airway epithelial cells may be important in the pathogenesis of subepithelial fibrosis, a distinctive lesion of chronic human asthma. Expand
Effects of anticytokine therapy in a mouse model of chronic asthma.
TLDR
It is concluded that inhibition of IL-5 is beneficial and that inhibitionof IL-13 has considerable potential as a therapeutic strategy in chronic asthma, that IFN-gamma may play an important role in the pathogenesis of AHR, and that co-operative interaction between Th2 and Th1 cytokines contributes to the pathogenic of the lesions of chronic asthma. Expand
[Airway remodeling in asthma].
TLDR
In the article the authors describe changes in airways wall in asthmatic patients and their clinical consequences. Expand
Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma
TLDR
Both roflumilast and dexamethasone were potent inhibitors of airway inflammation and remodeling in this model of chronic asthma, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids. Expand
Interleukin-17 and airway remodelling.
  • A. Lindén
  • Medicine
  • Pulmonary pharmacology & therapeutics
  • 2006
TLDR
Evidence in mice that endogenous IL- 17A contributes to the development of allergen-induced airway hyperresponsiveness and there is also evidence that IL-17A stimulates the release of several cytokines with known capacity for airway remodelling, from cells normally residing in the airways, may constitute a useful target for pharmacotherapeutic intervention in allergic airway disease. Expand
Cytokine-directed therapy in asthma.
TLDR
Because so many cytokines are involved in asthma, drugs that inhibit the synthesis of multiple cytokines may prove to be more useful; several such classes of drug are now in clinical development and any risk of side effects with these non-specific inhibitors may be reduced by the inhaled route. Expand
Dissociation of Inflammatory and Epithelial Responses in a Murine Model of Chronic Asthma
TLDR
It is concluded that interleukin-5, but not interleucin-4, plays a central role in the development of chronic inflammation of the airways and the induction of airway hyperreactivity. Expand
Modeling allergic asthma in mice: pitfalls and opportunities.
TLDR
An improved murine model in which animals are exposed to low mass concentrations of aerosolized antigen for 6-8 wk and exhibit airway-specific acute-on-chronic inflammation and changes of airway wall remodeling as seen in human asthma, together with hyperreactivity to a cholinergic agonist which can be specifically attributed to airway disease is developed. Expand
...
1
2
3
4
5
...