Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.

@article{Mutoh2000SuppressionOC,
  title={Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.},
  author={Michihiro Mutoh and Mami Takahashi and Kuniaki Fukuda and Yuko Matsushima-Hibiya and Hiroyuki Mutoh and Takashi Sugimura and Keiji Wakabayashi},
  journal={Carcinogenesis},
  year={2000},
  volume={21 5},
  pages={959-63}
}
Cyclooxygenase-2 (COX-2) is abundantly expressed in colon cancer cells. It has been reported that inhibition of COX-2 enzyme activity is shown to prevent colon carcinogenesis. Thus, suppression of COX-2 expression may also be an effective chemopreventive strategy. In the present study, we constructed a beta-galactosidase reporter gene system in human colon cancer DLD-1 cells, and measured COX-2 promoter-dependent transcriptional activity in the cells. Interferon gamma suppressed this COX-2… CONTINUE READING