Suppression of contact hypersensitivity in mice by ultraviolet irradiation is associated with defective antigen presentation.

@article{Noonan1981SuppressionOC,
  title={Suppression of contact hypersensitivity in mice by ultraviolet irradiation is associated with defective antigen presentation.},
  author={Frances P. Noonan and Margaret L. Kripke and G M Pedersen and M ichael Greene},
  journal={Immunology},
  year={1981},
  volume={43 3},
  pages={527-33}
}
A single dose of radiation from FS40 sunlamps results in systemic depression of delayed-type hypersensitivity (DTH) to 2-chloro-1,3,5-trinitrobenzene (TNCB) and 1-fluoro-2,4-dinitrobenzene (DNFB). Immunosuppression is proportional to the log10 dose of radiation and exhibits a delayed time course. Animals sensitized one day after ultraviolet (u.v.) treatment respond normally, but sensitization 3-15 days after treatment results in about 70% suppression of the DTH response. The dose response of… CONTINUE READING

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