Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility.

@article{Balaji2009SuppressionOC,
  title={Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility.},
  author={T. S. S. Balaji and S. Aruna and Manickam Ramanathan and Marimuthu Srinivasan and Venugopal Padmanabhan Menon},
  journal={Journal of basic and clinical physiology and pharmacology},
  year={2009},
  volume={20 4},
  pages={357-76}
}
Significant levels of constitutive cyclooxygenase-2 (COX-2) are present in the male reproductive organs of rodents, especially in the vas deferens and epididymis. In the epididymis, the sperm storehouse, COX-2 is thought to play a vital role in altering the membrane lipids of sperm. The present study aims at localizing COX-2 in the epididymis and analyzing the effects of the preferential COX-2 inhibitor nimesulide. COX-2 protein activity was nearly equal to that of COX-1 in the cauda epididymis… CONTINUE READING

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