Suppression of connective tissue growth factor mediates the renoprotective effect of Sitagliptin rather than Pioglitazone in type 2 diabetes mellitus.

@article{Ali2016SuppressionOC,
  title={Suppression of connective tissue growth factor mediates the renoprotective effect of Sitagliptin rather than Pioglitazone in type 2 diabetes mellitus.},
  author={Samia M Ali and Hoda Mahmoud Khalifa and Dalia K Mostafa and Amal El Sharkawy},
  journal={Life sciences},
  year={2016},
  volume={153},
  pages={180-7}
}
AIM Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin and Pioglitazone, versus combined Metformin/Enalapril in a rat model of type 2 diabetes. METHOD Male Wistar rats were randomly assigned to be either normal control or diabetic… CONTINUE READING
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