Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

  title={Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.},
  author={Alexander A. Chumanevich and Corey P. Causey and Bryan A Knuckley and J E Lennard Jones and D. Sharma Poudyal and Alena P. Chumanevich and Tia Davis and Lydia E. Matesic and Paul R Thompson and Lorne J. Hofseth},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={300 6},
Inflammatory bowel diseases (IBDs), mainly Crohn's disease and ulcerative colitis, are dynamic, chronic inflammatory conditions that are associated with an increased colon cancer risk. Inflammatory cell apoptosis is a key mechanism for regulating IBD. Peptidylarginine deiminases (PADs) catalyze the posttranslational conversion of peptidylarginine to peptidylcitrulline in a calcium-dependent, irreversible reaction and mediate the effects of proinflammatory cytokines. Because PAD levels are… CONTINUE READING

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A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2009

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