Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Abstract

Sphingolipid metabolism is driven by inflammatory cytokines. These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). Overall, S1P is one of the crucial components in inflammation, making SK an excellent target for the development of new… (More)
DOI: 10.1093/carcin/bgq158

Topics

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