Suppression of class I human histocompatibility leukocyte antigen by c- myc is locus specific

Abstract

The c-myc oncogene downregulates class I HLA expression in human melanoma. The major class I HLA antigens are encoded by three loci, A, B, and C, and we investigated whether these loci are suppressed equally by c-myc. In three melanoma cell lines with high c-myc expression, we analyzed mRNA, protein, and cell surface expression of the class I HLA antigens… (More)

Topics

6 Figures and Tables

Cite this paper

@article{Versteeg1989SuppressionOC, title={Suppression of class I human histocompatibility leukocyte antigen by c- myc is locus specific}, author={R. Versteeg and K M Kr{\"u}se-Wolters and Astrid Plomp and Astrid van Leeuwen and Nathan Stam and H L Ploegh and Dirk J. Ruiter and Peter Schrier}, journal={The Journal of Experimental Medicine}, year={1989}, volume={170}, pages={621 - 635} }