Suppression of cell-mediated immunity by street rabies virus

@article{Wiktor1977SuppressionOC,
  title={Suppression of cell-mediated immunity by street rabies virus},
  author={Tadeusz J. Wiktor and Peter C. Doherty and Hilary Prof Koprowski},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={145},
  pages={1617 - 1622}
}
  • Tadeusz J. Wiktor, Peter C. Doherty, Hilary Prof Koprowski
  • Published in
    The Journal of experimental…
    1977
  • Medicine, Biology
  • The Journal of Experimental Medicine
  • Mice lethally infected with street rabies virus failed to develop cytotoxic T cells specific for rabies virus-infected target cells, whereas high levels of cell-mediated cytotoxicity (CMC) were generated after nonfatal infection with the attenuated high egg passage (HEP) or ERA rabies virus strains. Furthermore concurrent infection with street, but not with HEP, rabies virus suppresses development of a primary (but not a secondary) CMC response specific for influenza virus. No cross-reactivity… CONTINUE READING

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