Suppression of cell-mediated immune responses to malaria antigens in pregnant Gambian women.

@article{Riley1989SuppressionOC,
  title={Suppression of cell-mediated immune responses to malaria antigens in pregnant Gambian women.},
  author={Eleanor M. Riley and Gisela Schneider and I Sambou and Brian Greenwood},
  journal={The American journal of tropical medicine and hygiene},
  year={1989},
  volume={40 2},
  pages={141-4}
}
In malaria endemic areas, pregnancy predisposes previously immune women to clinical and subclinical malaria infection. While parameters of humoral immunity do not seem to be affected by pregnancy, suppression of cellular immunity has been demonstrated for a number of antigens. In this study of women from a rural area of the Gambia where falciparum malaria is holoendemic, we show that lymphoproliferative responses to Plasmodium falciparum antigens are depressed in pregnant women compared to… CONTINUE READING
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