Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells

@article{Nasu1998SuppressionOC,
  title={Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells},
  author={Yasutomo Nasu and Terry L. Timme and Guang Yang and Chris H. Bangma and Likun Li and Chengzhen Ren and Sang Hee Park and M Deleon and Jianxiang Wang and Timothy C Thompson},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={1062-1064}
}
Although prostate cancer cells are often initially sensitive to androgen ablation, they eventually lose this response and continue to survive, grow and spread in the absence of androgenic steroids. The mechanism(s) that underlie resistance to androgen ablation therapy remain mostly unknown. We have demonstrated that elevated caveolin protein levels are associated with human prostate cancer progression in pathological specimens. Here we show that suppression of caveolin expression by a stably… CONTINUE READING
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