Suppression of cancer relapse and metastasis by inhibiting cancer stemness.

  title={Suppression of cancer relapse and metastasis by inhibiting cancer stemness.},
  author={Youzhi Li and Harry A Rogoff and Sarah Keates and Yuan Gao and Sylaja Murikipudi and Keith Mikule and David Leggett and Wei Li and Arthur B. Pardee and Chiang J. Li},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 6},
Partial or even complete cancer regression can be achieved in some patients with current cancer treatments. However, such initial responses are almost always followed by relapse, with the recurrent cancer being resistant to further treatments. The discovery of therapeutic approaches that counteract relapse is, therefore, essential for advancing cancer medicine. Cancer cells are extremely heterogeneous, even in each individual patient, in terms of their malignant potential, drug sensitivity, and… CONTINUE READING