Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis

@article{Geserick2008SuppressionOC,
  title={Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis},
  author={Peter Geserick and Claudia Drewniok and Mike Hupe and Tobias L. Haas and Philip Diessenbacher and Martin R Sprick and Michael P Sch{\"o}n and Frank Henkler and Harald P. M. Gollnick and Henning Walczak and Martin Leverkus},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={3211-3220}
}
Death ligands such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and certain forms of CD95L are attractive therapeutic options for metastatic melanoma. Since knowledge about the regulation of death receptor sensitivity in melanoma is sparse, we have analysed these signaling pathways in detail. The loss of CD95 or TRAIL-R1, but not of TRAIL-R2, surface expression correlated with apoptosis sensitivity in a panel of melanoma cell lines. In contrast, the expression of… CONTINUE READING

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