Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)

@article{Pan2006SuppressionOB,
  title={Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)},
  author={Yong Hua Pan and Lei Wang and Jia Le Dai},
  journal={Breast Cancer Research},
  year={2006},
  volume={8},
  pages={R63 - R63}
}
Na+/H+ exchanger regulatory factor 1 (NHERF1, also known as EBP50 or NHERF) is a putative tumour suppressor gene in human breast cancer. Located at 17q25.1, NHERF1 is frequently targeted during breast tumourigenesis. Loss of heterozygosity (LOH) at the NHERF1 locus is found in more than 50% of breast tumours. In addition, NHERF1 is mutated in a subset of primary breast tumours and breast cancer cell lines. LOH at the NHERF1 locus is strongly associated with aggressive features of breast tumours… CONTINUE READING
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