Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis

@article{Wheater2011SuppressionOB,
  title={Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis},
  author={Gillian Wheater and Vanessa E. Hogan and Yongping Teng and Janneke Tekstra and Floris PJG Lafeber and Tom W. J. Huizinga and Johannes W J Bijlsma Bijlsma and Roger M. Francis and Stephen Paul Tuck and Harish K. Datta and Jacob M. van Laar},
  journal={Osteoporosis International},
  year={2011},
  volume={22},
  pages={3067-3072}
}
The role of B cells in inflammatory bone formation and resorption is controversial. We investigated this in patients with rheumatoid arthritis (RA) treated with rituximab, a B-cell depleting antibody. We found a significant suppression in bone turnover, possibly a direct effect or as a consequence of a reduction in inflammation and disease activity. RA is the most prevalent inflammatory joint disease, in which B cells play an important role. However, the role of B cells in bone turnover is… CONTINUE READING
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Biologicals and bone loss.

Therapeutic advances in musculoskeletal disease • 2012
View 1 Excerpt
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References

Publications referenced by this paper.
Showing 1-10 of 29 references

The Disease Activity Score and the EULAR response criteria.

Rheumatic diseases clinics of North America • 2009
View 7 Excerpts
Highly Influenced

Use of bone turnover markers in the real world: are we there yet?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2009
View 1 Excerpt

Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis

F Chopin, P Garnero, +8 authors T Thomas
Ann Rheum Dis • 2008
View 1 Excerpt

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