Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

@article{Hayashi2002SuppressionOB,
  title={Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.},
  author={Masahiko Hayashi and M J Rho and Akiko Enomoto and Akiko Fukami and Y P Kim and Yuji Kikuchi and Toshiaki Sunazuka and Tomoyasu Hirose and Kanki Komiyama and Satoshi Ōmura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 23},
  pages={14728-33}
}
IL-6 is a multifunctional cytokine involved in regulation of differentiation, antibody production, and growth of certain types of tumor cells. Its excessive production plays a major role in pathogenesis of multiple myeloma and postmenopausal osteoporosis. In the course of a screening program aimed at IL-6 inhibitor from microbial products, we found madindoline A (MDL-A) and madindoline B, which have a fuloindoline structure with diketocyclopentene bound to the methyl group. MDL-A has no… CONTINUE READING
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