Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans

  title={Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans},
  author={Louise M F Doyle Gaynor and Andrea A. K{\"u}hn and Michele Dileone and Vladimir Litvak and Alexandre Eusebio and Alek Pogosyan and Alexandros G. Androulidakis and Steven Tisch and Patricia Limousin and Angelo Insola and Paolo A M Mazzone and Vincenzo Di Lazzaro and Peter Brown},
  journal={The European Journal of Neuroscience},
  pages={1686 - 1695}
It is unclear how subthalamic nucleus activity is modulated by the cerebral cortex. Here we investigate the effect of transcranial magnetic stimulation (TMS) of the cortex on oscillatory subthalamic local field potential activity in the 8-35 Hz (alpha/beta) band, as exaggerated synchronization in this band is implicated in the pathophysiology of parkinsonism. We studied nine patients with Parkinson's disease (PD) to test whether cortical stimulation can modulate synchronized oscillations in the… CONTINUE READING
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