Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.

  title={Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.},
  author={Satona Tanaka and Teruo Murakami and Hideki Horikawa and Makoto Sugiura and Kohtaro Kawashima and Takahisa Sugita},
  journal={International journal of immunopharmacology},
  volume={19 1},
Dipeptidyl peptidase IV (DP IV, CD26) is a serine exoprotease which selectively cleaves the penultimate proline residue of polypeptides. This enzyme is also expressed as a surface marker on activated T cells. In order to assess the relevance of DP IV in immunological disorders, we evaluated the in vivo effects of specific DP IV inhibitors using two arthritis models, one which was induced by collagen one by alkyldiamine. These animal models share several pathological features associated with… CONTINUE READING
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