Suppression of arthritis by an inhibitor of nitric oxide synthase

  title={Suppression of arthritis by an inhibitor of nitric oxide synthase},
  author={Nancy L. McCartney-Francis and Janice B. Allen and Diane E. Mizel and Jorge E. Albina and Qiao-wen Xie and Carl Nathan and Sharon M. Wahl},
  journal={The Journal of Experimental Medicine},
  pages={749 - 754}
Nitric oxide (NO), a toxic radical gas produced during the metabolism of L-arginine by NO synthase (NOS), has been implicated as a mediator of immune and inflammatory responses. A single injection of streptococcal cell wall fragments (SCW) induces the accumulation of inflammatory cells within the synovial tissue and a cell-mediated immune response that leads destructive lesions. We show here that NO production is elevated in the inflamed joints of SCW-treated rats. Administration of NG… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 156 extracted citations


Publications referenced by this paper.
Showing 1-10 of 29 references

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

  • Xie, Q.-w, +7 authors C. Nathan
  • Science (Wash. DC)
  • 1992
1 Excerpt

Similar Papers

Loading similar papers…