Suppression of arachidonic acid cascade-mediated apoptosis in aflatoxin B1-induced rat hepatoma cells by glucocorticoids.

@article{Iida1998SuppressionOA,
  title={Suppression of arachidonic acid cascade-mediated apoptosis in aflatoxin B1-induced rat hepatoma cells by glucocorticoids.},
  author={N. Iida and A. Sugiyama and H. Myoubudani and K. Inoue and M. Sugamata and T. Ihara and Y. Ueno and F. Tashiro},
  journal={Carcinogenesis},
  year={1998},
  volume={19 7},
  pages={
          1191-202
        }
}
It has been shown that hypophysectomy protects aflatoxin B1 (AFB1) hepatocarcinogenesis and the prevention of apoptosis is a critical process for tumorigenesis. In this paper, we analyzed the cell death of AFB1-induced rat hepatoma Kagura-2 (K2) cells elicited by an estrogen antagonist, tamoxifen (TAM), and transforming growth factor-beta1 (TGF-beta1) to elucidate the function of endocrine factors in AFB1 hepatocarcinogenesis. TAM and TGF-beta1 induced a typical apoptosis in K2 cells. The… Expand
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Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways
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